Evaluation of ERBB2 gene status and chromosome 17 anomalies in male breast cancer
RR Fonseca, AR Tomás, S André… - The American journal of …, 2006 - journals.lww.com
Male breast cancer (MBC) is an uncommon neoplasm that shares several biologic
characteristics with its female counterpart. In the latter, abnormalities in the expression
and/or copy number of the ERBB2 gene are present in 10% to 30% of invasive carcinoma
and behave as poor prognostic markers. ERBB2 abnormalities have also been reported in
MBC, yet at lower frequency, but their prognostic significance remains controversial.
Furthermore, no study has addressed the impact of chromosome 17 abnormalities in MBC …
characteristics with its female counterpart. In the latter, abnormalities in the expression
and/or copy number of the ERBB2 gene are present in 10% to 30% of invasive carcinoma
and behave as poor prognostic markers. ERBB2 abnormalities have also been reported in
MBC, yet at lower frequency, but their prognostic significance remains controversial.
Furthermore, no study has addressed the impact of chromosome 17 abnormalities in MBC …
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